Inhibition of invasion of epithelial cells by Tiam1-Rac signaling.

  title={Inhibition of invasion of epithelial cells by Tiam1-Rac signaling.},
  author={Peter L Hordijk and Jean P. ten Klooster and Rob A. van der Kammen and Frits Michiels and Lauran C. J. M. Oomen and John G. Collard},
  volume={278 5342},
Tiam1 encodes an exchange factor for the Rho-like guanosine triphosphatase Rac. Both Tiam1 and activated RacV12 promote invasiveness of T lymphoma cells. In epithelial Madin-Darby canine kidney (MDCK) cells, Tiam1 localized to adherens junctions. Ectopic expression of Tiam1 or RacV12 inhibited hepatocyte growth factor-induced scattering by increasing E-cadherin-mediated cell-cell adhesion accompanied by actin polymerization at cell-cell contacts. In Ras-transformed MDCK cells, expression of… CONTINUE READING
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