Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1.

@article{Kreuter1990InhibitionOI,
  title={Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1.},
  author={M H Kreuter and Robin E. Leake and Frank A Rinaldi and Wolfgang Mueller-Klieser and Armin Maidhof and Walter E. Mueller and Heinz C Schr{\"o}der},
  journal={Comparative biochemistry and physiology. B, Comparative biochemistry},
  year={1990},
  volume={97 1},
  pages={
          151-8
        }
}
1. (+)-Aeroplysinin-1, a naturally occurring tyrosine metabolite from the marine sponge Verongia aerophoba, was found to inhibit the phosphorylation of lipocortin-like proteins by a highly purified preparation of the epidermal growth factor (EGF) receptor-tyrosine protein kinase complex from MCF-7 breast carcinoma cells. 2. (+)-Aeroplysinin-1 blocked the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibited the ligand-induced endocytosis of the EGF… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

Synthesis and anticancer evaluation of spermatinamine analogues.

  • Bioorganic & medicinal chemistry letters
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND