Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632.

@article{Takamura2001InhibitionOI,
  title={Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632.},
  author={Masaaki Takamura and Michiie Sakamoto and Takuya Genda and Takafumi Ichida and Hitoshi Asakura and Setsuo Hirohashi},
  journal={Hepatology},
  year={2001},
  volume={33 3},
  pages={577-81}
}
Intrahepatic metastasis is one of the most important prognostic factors for patients with hepatocellular carcinoma (HCC). Cell motility mediated by Rho- and p160 Rho-associated coiledcoil forming protein kinase (p160ROCK) signaling pathways has recently been shown to play a critical role in intrahepatic metastasis in human HCC. Furthermore, the stable introduction of dominant-negative p160ROCK into Li7 cells resulted in a reduced metastatic rate in mice with severe combined immunodeficiency… CONTINUE READING