Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice.

@article{Arenberg1996InhibitionOI,
  title={Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice.},
  author={Douglas Arenberg and Steven L. Kunkel and Peter J. Polverini and Michelle Glass and Marie D. Burdick and Robert M. Strieter},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 12},
  pages={2792-802}
}
The salient feature of solid tumor growth is the strict dependence on local angiogenesis. We have previously demonstrated that IL-8 is an angiogenic factor present in freshly isolated specimens of human non-small cell lung cancer (NSCLC). Using a model of human NSCLC tumorigenesis in SCID mice, we now report that IL-8 acts as a promoter of human NSCLC tumor growth through its angiogenic properties. Passive immunization with neutralizing antibodies to IL-8 resulted in more than 40% reduction in… CONTINUE READING

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