Inhibition of interleukin-12 expression by alpha-thrombin in human peripheral blood mononuclear cells: a potential mechanism for modulating Th1/Th2 responses.

@article{Naldini2003InhibitionOI,
  title={Inhibition of interleukin-12 expression by alpha-thrombin in human peripheral blood mononuclear cells: a potential mechanism for modulating Th1/Th2 responses.},
  author={Antonella Naldini and Lucien A. Aarden and Annalisa Pucci and Claudia Bernini and Fabio Carraro},
  journal={British journal of pharmacology},
  year={2003},
  volume={140 5},
  pages={980-6}
}
In addition to its central role in blood coagulation and hemostasis, human alpha-thrombin is a powerful regulator of inflammatory responses and is known to affect cell-mediated immunity. Interleukin (IL)-12 is a strong promoter of the development of Th1-type lymphocytes and its downregulation implies a positive feedback mechanism for development of Th2… CONTINUE READING