Inhibition of interleukin-1 by anakinra improves vascular and left ventricular function in patients with rheumatoid arthritis.

@article{Ikonomidis2008InhibitionOI,
  title={Inhibition of interleukin-1 by anakinra improves vascular and left ventricular function in patients with rheumatoid arthritis.},
  author={Ignatios Ikonomidis and John P. Lekakis and Maria Nikolaou and Ioannis A. Paraskevaidis and Ioanna T Andreadou and Theophania Kaplanoglou and Pelagia Katsimbri and Grigorios Skarantavos and Panayiotis N. Soucacos and Dimitrios T h Kremastinos},
  journal={Circulation},
  year={2008},
  volume={117 20},
  pages={2662-9}
}
BACKGROUND Interleukin-1 increases nitrooxidative stress. We investigated the effects of a human recombinant interleukin-1a receptor antagonist (anakinra) on nitrooxidative stress and vascular and left ventricular function. METHODS AND RESULTS In an acute, double-blind trial, 23 patients with rheumatoid arthritis were randomized to receive a single injection of anakinra (150 mg s.c.) or placebo and, after 48 hours, the alternative treatment. At baseline and 3 hours after the injection, we… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 93 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Cardiovascular disease in rheumatoid arthritis

  • MJ Kaplan
  • Curr Opin Rheumatol
  • 2006

Similar Papers

Loading similar papers…