Inhibition of interleukin 1 beta induced rat and human cartilage degradation in vitro by the metalloproteinase inhibitor U27391.

@article{Seed1993InhibitionOI,
  title={Inhibition of interleukin 1 beta induced rat and human cartilage degradation in vitro by the metalloproteinase inhibitor U27391.},
  author={Michael Peter Seed and S A Ismaiel and Catherine Wing Ying Cheung and Thomas A. Thomson and Colin R. Gardner and Roger Atkins and Christopher J. Elson},
  journal={Annals of the rheumatic diseases},
  year={1993},
  volume={52 1},
  pages={37-43}
}
Interleukin 1 induced proteoglycan loss from cartilage in vitro was prevented by a biochemical inhibitor of metalloproteinase activity. The inhibitor also partially relieved the inhibition of proteoglycan synthesis caused by interleukin 1. The loss of glycosaminoglycan by rat and human femoral head cartilage in response to human recombinant interleukin 1… CONTINUE READING