Inhibition of interferon-inducible gene expression by adenovirus E1A proteins: block in transcriptional complex formation.

@article{Kalvakolanu1991InhibitionOI,
  title={Inhibition of interferon-inducible gene expression by adenovirus E1A proteins: block in transcriptional complex formation.},
  author={Dhananjaya V. Kalvakolanu and Sudip K. Bandyopadhyay and Marian L. Harter and Ganes C Sen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 17},
  pages={7459-63}
}
Infection with wild-type adenovirus 5, but not with a mutant lacking the E1A gene, prevented the induction by interferon (IFN) alpha of chloramphenicol acetyltransferase (CAT) activity in HeLaM cell lines that had been permanently transfected with chimeric CAT reporter genes driven by the transcriptional regulatory regions of the IFN-responsive genes 561 and 6-16. Similar inhibition of IFN-inducible CAT activity was observed in cells that were cotransfected with the same reporter genes and… CONTINUE READING

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