Inhibition of insulin signaling by oxidized low density lipoprotein. Protective effect of the antioxidant Vitamin E.

@article{Mazire2004InhibitionOI,
  title={Inhibition of insulin signaling by oxidized low density lipoprotein. Protective effect of the antioxidant Vitamin E.},
  author={C{\'e}cile Mazi{\`e}re and Patrice Morli{\`e}re and Ren{\'e} Santus and Virginie Marcheux and Christophe Louandre and Marie-Alix Conte and J. C. Mazi{\`e}re},
  journal={Atherosclerosis},
  year={2004},
  volume={175 1},
  pages={23-30}
}
Oxidative stress is involved in several pathological conditions, including diabetes. Reactive oxygen species (ROS) have been demonstrated to act as second messengers for several hormones and cytokines, including insulin (INS). The effect of Cu(2+)-oxidized LDL (CuLDL) on INS-induced generation of ROS and on INS signaling was investigated on cultured human… CONTINUE READING