Inhibition of insulin-like growth factor binding protein 5 proteolysis in articular cartilage and joint fluid results in enhanced concentrations of insulin-like growth factor 1 and is associated with improved osteoarthritis.

@article{Clemmons2002InhibitionOI,
  title={Inhibition of insulin-like growth factor binding protein 5 proteolysis in articular cartilage and joint fluid results in enhanced concentrations of insulin-like growth factor 1 and is associated with improved osteoarthritis.},
  author={David Robert Clemmons and Walker H. Busby and Aaron Garmong and Duane R. Schultz and D. Shannon Howell and Roy Altman and Robert W. Karr},
  journal={Arthritis and rheumatism},
  year={2002},
  volume={46 3},
  pages={694-703}
}
OBJECTIVE The complement component C1s is present in dog joint fluid in an activated state. Since C1s degrades insulin-like growth factor binding protein 5 (IGFBP-5), we undertook to determine whether inhibiting C1s in joint fluid would result in an increase in the amount of intact IGFBP-5 and IGF-1 in cartilage and joint fluid, and whether C1s inhibition… CONTINUE READING