Inhibition of insulin like growth factor II autocrine growth of Wilms' tumor by suramin in vitro and in vivo.

@article{Vincent1996InhibitionOI,
  title={Inhibition of insulin like growth factor II autocrine growth of Wilms' tumor by suramin in vitro and in vivo.},
  author={Timothy S. Vincent and D. Hazen-martin and Abbott Julian Garvin},
  journal={Cancer letters},
  year={1996},
  volume={103 1},
  pages={
          49-56
        }
}
Suramin was found to affect the Wilms' tumor (WT) cell line, W13, by inhibiting in vitro growth (half-maximal inhibitory dose (ID50)=11 microM), insulin like growth factor II (IGF-II) cell binding (ID50 = 10 microM) and IGF-II induced DNA synthesis (ID50 = 8 microM). In addition, suramin inhibited cross-linking of [125I]IGF-II to the type 1 IGF receptor (IGF1R) and type 2 IGF receptor (IGF2R). Disruption of IGF-II/IGF1R interaction appears to be the main mode of action of suramin since the… CONTINUE READING

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