Inhibition of insect acetylcholinesterase by the potato glycoalkaloid alpha-chaconine.

@article{Wierenga1992InhibitionOI,
  title={Inhibition of insect acetylcholinesterase by the potato glycoalkaloid alpha-chaconine.},
  author={Jehoshua Eliashberg Jedid - Jah Jonker Mohanbir S. Sawhney Wierenga and Robert M. Hollingworth},
  journal={Natural toxins},
  year={1992},
  volume={1 2},
  pages={96-9}
}
Homogenates from several insect species were assayed for inhibition of acetylcholinesterase by the potato glycoalkaloid alpha-chaconine. Colorado potato beetle acetylcholinesterase was up to 150-fold less sensitive than other species tested. Acetylcholinesterase from an insecticide-resistant strain of Colorado potato beetles was more sensitive to inhibition than the susceptible strain. Most insect species tested had inhibitory concentrations causing a 50% reduction in activity in the 5 to 40… CONTINUE READING

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