Inhibition of injury‐induced glial aromatase reveals a wave of secondary degeneration in the songbird brain

@article{Wynne2008InhibitionOI,
  title={Inhibition of injury‐induced glial aromatase reveals a wave of secondary degeneration in the songbird brain},
  author={Ryan D. Wynne and Bradley J Walters and David J. Bailey and Colin Saldanha},
  journal={Glia},
  year={2008},
  volume={56}
}
Mechanical or anoxic/ischemic brain insult results in reactive gliosis and a pronounced wave of apoptotic secondary degeneration (WSD). Reactive glia express aromatase (estrogen synthase) and glial estrogen synthesis decreases apoptosis and the volume of degeneration. Whether aromatization by glia affects gliosis itself or the initiation/maintenance of the WSD remains unknown. Adult male zebra finches (Taeniopygia guttata) were injured with a needle that contained the aromatase inhibitor… Expand
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