Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo.

@article{Pinto2011InhibitionOI,
  title={Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo.},
  author={Ruth Pinto and Susanne Herold and Lidija Cakarova and Katrin Hoegner and Juergen Lohmeyer and Oliver Planz and Stephan Pleschka},
  journal={Antiviral research},
  year={2011},
  volume={92 1},
  pages={45-56}
}
Influenza virus (IV) infection can cause severe pneumonia and death. Therapeutic actions are limited to vaccines and a few anti-viral drugs. These target viral functions thereby selecting resistant variants. During replication IV activates the Raf/MEK/ERK-cascade and the transcription factor NF-kappaB. Both result in virus supportive and anti-viral effects by promoting viral genome transport for virus assembly and by inducing expression of pro-inflammatory host factors. Apart from tissue damage… CONTINUE READING

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