Inhibition of influenza-induced membrane fusion by lysophosphatidylcholine.

  title={Inhibition of influenza-induced membrane fusion by lysophosphatidylcholine.},
  author={S G{\"u}nther-Ausborn and Asja Praetor and Toon Stegmann},
  journal={The Journal of biological chemistry},
  volume={270 49},
Lysolipids have been reported to inhibit various membrane fusion events, and it was suggested that inhibition was due to their "inverted cone" shape, which hinders the formation of intermediate lipid structures required for fusion (Chernomordik, L. V., Vogel, S. S., Sokoloff, A., Onaran, H. O., Leikina, E. A., and Zimmerberg, J. (1993) FEBS Lett. 318, 71-76). Here, the effect of lysophosphatidylcholine (LPC) on fusion mediated by the hemagglutinin (HA) of influenza virus was investigated. Virus… CONTINUE READING

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