Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin

@inproceedings{Piktel2019InhibitionOI,
  title={Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin},
  author={Ewelina Piktel and Urszula Wnorowska and Mateusz Cieśluk and Piotr Deptula and Katarzyna Pogoda and Iwona Misztalewska-Turkowicz and Paulina Paprocka and Katarzyna Niemirowicz-Laskowska and Agnieszka Z. Wilczewska and Paul A. Janmey and Robert Bucki},
  booktitle={Journal of Nanobiotechnology},
  year={2019}
}
BackgroundHuman plasma gelsolin (pGSN) is a multifunctional actin-binding protein involved in a variety of biological processes, including neutralization of pro-inflammatory molecules such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA) and modulation of host inflammatory response. It was found that PBP10, a synthetic rhodamine B-conjugated peptide, based on the phosphoinositide-binding site of pGSN, exerts bactericidal activity against Gram-positive and Gram-negative bacteria… CONTINUE READING

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