Inhibition of inflammatory endothelial responses by a pathway involving caspase activation and p65 cleavage.

@article{Neuzil2001InhibitionOI,
  title={Inhibition of inflammatory endothelial responses by a pathway involving caspase activation and p65 cleavage.},
  author={Jiri Neuzil and Andreas Schroeder and Philipp von Hundelshausen and Alma Zernecke and Thomas Weber and Nina Gellert and Cs Weber},
  journal={Biochemistry},
  year={2001},
  volume={40 15},
  pages={
          4686-92
        }
}
Suppression of NF kappa B activation has been involved in the elimination of survival programs during endothelial cell (EC) apoptosis. We used alpha-tocopheryl succinate (alpha-TOS) to trigger apoptosome formation and the subsequent activation of executioner caspases. The level of bcl-2 was reduced by alpha-TOS, and its downregulation potentiated and its overexpression suppressed pro-apoptotic effects of alpha-TOS, indicating a mitochondrial role in alpha-TOS-induced apoptosis in EC. alpha-TOS… CONTINUE READING

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