Inhibition of inflammasome activation improves lung acute injury induced by carrageenan in a mouse model of pleurisy.

@article{Fusco2017InhibitionOI,
  title={Inhibition of inflammasome activation improves lung acute injury induced by carrageenan in a mouse model of pleurisy.},
  author={Roberta Fusco and Enrico Gugliandolo and Flavia Biundo and Michela Campolo and Rosanna di Paola and Salvatore Cuzzocrea},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2017},
  volume={31 8},
  pages={3497-3511}
}
The inflammasome NLRP3 is a molecular pathway activated by a wide range of cellular insults to elicit innate immune defenses through the activation of caspase-1 and the maturation of proinflammatory cytokines, such as IL-1β and IL-18. The expression of NRLP3 is abnormally elevated in numerous human inflammatory diseases, including pulmonary diseases. An injection of carrageenan (CAR) into the pleural cavity triggered an acute inflammatory response, leading to tissue damage, inflammatory… CONTINUE READING
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