Inhibition of inducible nitric oxide synthase reverses the loss of functional hyperemia in diabetic retinopathy.

@article{Mishra2010InhibitionOI,
  title={Inhibition of inducible nitric oxide synthase reverses the loss of functional hyperemia in diabetic retinopathy.},
  author={Anusha Mishra and Eric A Newman},
  journal={Glia},
  year={2010},
  volume={58 16},
  pages={1996-2004}
}
Neuronal activity leads to arteriole dilation and increased blood flow in retinal vessels. This response, termed functional hyperemia, is diminished in the retinas of diabetic patients, possibly contributing to the development of diabetic retinopathy. The mechanism responsible for this loss is unknown. Here we show that light-evoked arteriole dilation was reduced by 58% in a streptozotocin-induced rat model of type 1 diabetes. Functional hyperemia is believed to be mediated by glial cells and… CONTINUE READING
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