Inhibition of inducible nitric oxide synthase lowers the cochlear damage by lipopolysaccharide in guinea pigs.

Abstract

Endotoxin-treated cochleas of the guinea pig were examined electrophysiologically and immunohistochemically concerning the expression of inducible nitric oxide synthase (iNOS/NOS II). One mg of bacterial lipopolysaccharide (LPS, 5 mg/ml) or mixed solution of 1 mg of LPS plus 1 mg of N(G)-nitro-L-arginine methyl ester (L-NAME, 5 mg/ml) (L-NAME/LPS) was… (More)

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@article{Watanabe2000InhibitionOI, title={Inhibition of inducible nitric oxide synthase lowers the cochlear damage by lipopolysaccharide in guinea pigs.}, author={Kojiro Watanabe and A. Hess and Witold M Bloch and O. Michel}, journal={Free radical research}, year={2000}, volume={32 4}, pages={363-70} }