Inhibition of inducible nitric oxide synthase results in reductions in wound vascular endothelial growth factor expression, granulation tissue formation, and local perfusion.

@article{Howdieshell2003InhibitionOI,
  title={Inhibition of inducible nitric oxide synthase results in reductions in wound vascular endothelial growth factor expression, granulation tissue formation, and local perfusion.},
  author={Thomas R. Howdieshell and Whitney L Webb and Sathyanarayana and Paul McNeil},
  journal={Surgery},
  year={2003},
  volume={133 5},
  pages={528-37}
}
BACKGROUND Wound repair results from a series of highly orchestrated cellular and biochemical events, including increased synthesis of the bioregulatory molecule nitric oxide (NO). The goal of this work was to test the functional role of NO in promotion of vascular endothelial growth factor (VEGF) production and the vigorous granulation tissue formation characteristic of this wound model. METHODS A ventral hernia, surgically created in the abdominal walls of 12 swine, was repaired with… CONTINUE READING

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