Inhibition of in vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody.

@article{Joseph2010InhibitionOI,
  title={Inhibition of in vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody.},
  author={Aviva Joseph and Jian Hua Zheng and Ken Chen and Monica Dutta and Cindy Chen and Gabriela M Stiegler and Renate E Kunert and Antonia Follenzi and Harris Goldstein},
  journal={Journal of virology},
  year={2010},
  volume={84 13},
  pages={6645-53}
}
Due to the inherent immune evasion properties of the HIV envelope, broadly neutralizing HIV-specific antibodies capable of suppressing HIV infection are rarely produced by infected individuals. We examined the feasibility of utilizing genetic engineering to circumvent the restricted capacity of individuals to endogenously produce broadly neutralizing HIV-specific antibodies. We constructed a single lentiviral vector that encoded the heavy and light chains of 2G12, a broadly neutralizing anti… CONTINUE READING
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