Inhibition of in vitro ovarian cancer cell invasion by modulation of urokinase-type plasminogen activator and cathepsin B.

@article{Kobayashi1992InhibitionOI,
  title={Inhibition of in vitro ovarian cancer cell invasion by modulation of urokinase-type plasminogen activator and cathepsin B.},
  author={Hiromasa Kobayashi and Hidekazu Ohi and Motoi Sugimura and Hiromitsu Shinohara and Takuma Fujii and Toshihiko Terao},
  journal={Cancer research},
  year={1992},
  volume={52 13},
  pages={
          3610-4
        }
}
HOC-I ovarian cancer cells express the single-chain form of the urokinase-type plasminogen activator (uPA) and cathepsin B (cath B) on their cell surface. The significance of the expression of cell surface uPA/cath B activity to the invasive potential was examined by preincubating with uPA/cath B-modulating agents in in vitro invasion assay. The anti-uPA monoclonal antibody 394 effectively inhibited invasion in a dose-dependent manner. On the contrary, anti-cath B antibody did not affect the… CONTINUE READING
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