Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors.

@article{Wu1999InhibitionOI,
  title={Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors.},
  author={Jian Wu and Jian-Xiong Chen and Taube P Rothman and Michael David Gershon},
  journal={Development},
  year={1999},
  volume={126 6},
  pages={1161-73}
}
The terminal colon is aganglionic in mice lacking endothelin-3 or its receptor, endothelin B. To analyze the effects of endothelin-3/endothelin B on the differentiation of enteric neurons, E11-13 mouse gut was dissociated, and positive and negative immunoselection with antibodies to p75(NTR )were used to isolate neural crest- and non-crest-derived cells. mRNA encoding endothelin B was present in both the crest-and non-crest-derived cells, but that encoding preproendothelin-3 was detected only… CONTINUE READING

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