Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene [published erratum appears in J Exp Med 1989 Aug 1;170(2):619]

@article{Hagman1989InhibitionOI,
  title={Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene [published erratum appears in J Exp Med 1989 Aug 1;170(2):619]},
  author={James Hagman and David Lo and L T Doglio and John Hackett and Charles M Rudin and Deanna L Haasch and Ralph L. Brinster and Ursula Storb},
  journal={The Journal of Experimental Medicine},
  year={1989},
  volume={169},
  pages={1911 - 1929}
}
The rearrangement of Ig genes is known to be regulated by the production of H and kappa L chains. To determine whether lambda L chains have a similar effect, transgenic mice were produced with a lambda 2 gene. It was necessary to include the H chain enhancer, since a lambda gene without the added enhancer did not result in transgene expression. The lambda 2 transgene with the H enhancer was expressed in lymphoid cells only. The majority of the B cells of newborn transgenic mice produced lambda… CONTINUE READING
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