Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits.

@article{Higaki1998InhibitionOI,
  title={Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits.},
  author={J. Higaki and S. Hara and N. Takasu and K. Tonda and K. Miyata and T. Shike and K. Nagata and T. Mizui},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1998},
  volume={18 8},
  pages={
          1304-11
        }
}
  • J. Higaki, S. Hara, +5 authors T. Mizui
  • Published 1998
  • Biology, Medicine
  • Arteriosclerosis, thrombosis, and vascular biology
The ileal Na+/bile acid cotransporter (IBAT) plays an important role in the enterohepatic circulation of bile acids. We investigated the effects of IBAT inhibition on the maintenance of serum cholesterol level by using a novel IBAT inhibitor, S-8921, in rabbits. Administration of S-8921 by its incorporation into the diet (0.01% to 0.1%) for 1 to 2 weeks in heterozygous Watanabe heritable hyperlipidemic rabbits decreased serum cholesterol by 29% to 37% and increased fecal excretion of measured… Expand
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References

SHOWING 1-10 OF 56 REFERENCES
Effects of novel bile salts on cholesterol metabolism in rats and guinea-pigs.
  • 17
Mechanism of hypocholesterolemic action of S-8921 in rats: S-8921 inhibits ileal bile acid absorption.
  • 43
  • PDF
Effects of 2164U90 on ileal bile acid absorption and serum cholesterol in rats and mice.
  • 56
Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035.
  • 174
Active and passive bile acid absorption in man. Perfusion studies of the ileum and jejunum.
  • 205
...
1
2
3
4
5
...