Inhibition of iNOS protects endothelial-dependent vasodilation in aged rats

  title={Inhibition of iNOS protects endothelial-dependent vasodilation in aged rats},
  author={Jue Tian and Zi Jun Yan and Ye Wu and Su-li Zhang and Ke Wang and Xiu-rui Ma and L F Guo and Juan Wang and Lin Zuo and Jing-yi Liu and Lin Quan and Hui-Rong Liu},
  booktitle={Acta Pharmacologica Sinica},
AbstractAim:To examine whether iNOS contributes to endothelial dysfunction in aged rats.Methods:Male Sprague Dawley rats were divided into three groups: young rats, aged rats treated with vehicle and aged rats treated with N-[3-(Aminomethyl) benzyl] acetamidine (1400W, 1 mg/kg, ip). Vasorelaxation was measured in isolated thoracic aorta. iNOS expression of thoracic aortic arteries was detected using immunohistochemistry and Western blot. Nitrotyrosine (a marker for peroxynitrite formation… CONTINUE READING
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Nitric oxide, superoxide, and peroxynitrite

JS Beckman, WH Koppenol
Res Rev • 2010

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