Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence.

@article{Montezuma2012InhibitionOI,
  title={Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence.},
  author={Karina Montezuma and Caroline Biojone and Sabrina Francesca Lisboa and Fernando Q Cunha and Francisco S Guimar{\~a}es and S{\^a}mia R. L. Joca},
  journal={Neuropharmacology},
  year={2012},
  volume={62 1},
  pages={485-91}
}
Recent evidence has suggested that systemic administration of non-selective NOS inhibitors induces antidepressant-like effects in animal models. However, the precise involvement of the different NOS isoforms (neuronal-nNOS and inducible-iNOS) in these effects has not been clearly defined yet. Considering that mediators of the inflammatory response, that are able to induce iNOS expression, can be increased by exposure to stress, the aim of the present study was to investigate iNOS involvement in… CONTINUE READING
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