Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalan.

@article{Hu2009InhibitionOH,
  title={Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalan.},
  author={Yongzhen Hu and Keita Kirito and Kozue Yoshida and Toru Mitsumori and Kei Nakajima and Y Nozaki and Satoshi Hamanaka and Takahiro Nagashima and Masae Kunitama and Kumi Sakoe and Norio Komatsu},
  journal={Molecular cancer therapeutics},
  year={2009},
  volume={8 8},
  pages={2329-38}
}
Abnormal activation of hypoxia-inducible factor-1 (HIF-1), one of the most important transcription factors for the adaptation of cells to hypoxia, is frequently observed in numerous types of solid tumors. Dysregulation of HIF-1 induces tumor angiogenesis and enhances the expression of anti-apoptotic proteins and glycolysis-associated enzymes in cancer cells, which in turn leads to the promotion of tumor growth. In the present study, we examined the pathophysiologic role of HIF-1 in multiple… CONTINUE READING

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