Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1

@article{Ozaki2003InhibitionOH,
  title={Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1},
  author={M. Ozaki and Sanae Haga and Hui Qi Zhang and Kaikobad Irani and Seiichi Suzuki},
  journal={Cell Death and Differentiation},
  year={2003},
  volume={10},
  pages={508-515}
}
AbstractRac1-regulated reactive oxygen species (ROS) production has been implicated in apoptosis. In contrast, pleiotropic protein kinase Akt protects against apoptosis. However, the pro- and antiapoptotic mechanisms of rac1 and Akt, respectively, and the intersection between these mechanisms are incompletely understood. In a model of oxidative stress and apoptosis induced by hypoxia/reoxygenation (H/R) in primary hepatocytes, activation of the PI3–K Akt axis by the prosurvival hepatocyte… CONTINUE READING