Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production


The enzyme carnitine palmitoyltransferase-1 (CPT1) regulates long-chain fatty acid (LCFA) entry into mitochondria, where the LCFAs undergo β-oxidation. To investigate the mechanism(s) by which central metabolism of lipids can modulate energy balance, we selectively reduced lipid oxidation in the hypothalamus. We decreased the activity of CPT1 by… (More)
DOI: 10.1038/nm873


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