Inhibition of hyaluronan export from human fibroblasts by inhibitors of multidrug resistance transporters.

@article{Prehm2004InhibitionOH,
  title={Inhibition of hyaluronan export from human fibroblasts by inhibitors of multidrug resistance transporters.},
  author={Peter Prehm and Udo Schumacher},
  journal={Biochemical pharmacology},
  year={2004},
  volume={68 7},
  pages={1401-10}
}
In a previous report we described the export of hyaluronan from Streptococcus pyogenes by an ABC transporter. Extending these findings a sequence homology search against human proteins revealed a strong homology to the multidrug resistance transporter ABC-B (MDR-1) and ABC-C (MRP 5). Using several inhibitors directed against these and other transporters, a decreased hyaluronan production in cell culture as well as in hyaluronan synthase activity in purified membrane fractions was observed. The… CONTINUE READING