Inhibition of human telomerase enhances the effect of the tyrosine kinase inhibitor, imatinib, in BCR-ABL-positive leukemia cells.

@article{Tauchi2002InhibitionOH,
  title={Inhibition of human telomerase enhances the effect of the tyrosine kinase inhibitor, imatinib, in BCR-ABL-positive leukemia cells.},
  author={Tetsuzo Tauchi and Akihiro Nakajima and Goro Sashida and Takashi Shimamoto and Junko H Ohyashiki and Kenji Abe and Kohtaro Yamamoto and Kazuma Ohyashiki},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 11},
  pages={3341-7}
}
PURPOSE Telomerase is a ribonucleoprotein enzyme that maintains protective structures at the ends of eukaryotic chromosomes. Earlier findings have supported an association between progressive telomere shortening in the chronic phase of chronic myelogenous leukemia and the up-regulation of telomerase activity occurring late in the evolution of the disease. We examined the impact of telomerase inhibition by dominant negative-human telomerase reverse transcriptase (DN-hTERT) on the biological… CONTINUE READING

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