Inhibition of human respiratory syncytial virus infectivity by a dendrimeric heparan sulfate-binding peptide.

  title={Inhibition of human respiratory syncytial virus infectivity by a dendrimeric heparan sulfate-binding peptide.},
  author={Manuela Donalisio and Marco Rusnati and Valeria Cagno and Andrea Civra and Antonella Bugatti and Andrea Giuliani and Giovanna Pirri and Marco Volante and Mauro Papotti and Santo Landolfo and David Lembo},
  journal={Antimicrobial agents and chemotherapy},
  volume={56 10},
Respiratory syncytial virus (RSV) interacts with cell surface heparan sulfate proteoglycans (HSPGs) to initiate infection. The interaction of RSV with HSPGs thus presents an attractive target for the development of novel inhibitors of RSV infection. In the present study, a minilibrary of linear, dimeric, and dendrimeric peptides containing clusters of basic amino acids was screened with the aim of identifying peptides able to bind HSPGs and thus block RSV attachment and infectivity. Of the… CONTINUE READING
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