Inhibition of human recombinant T-type calcium channels by N-arachidonoyl 5-HT.

@article{Gilmore2012InhibitionOH,
  title={Inhibition of human recombinant T-type calcium channels by N-arachidonoyl 5-HT.},
  author={Andrew J Gilmore and Marika Heblinski and Aaron J Reynolds and Michael Kassiou and Mark Connor},
  journal={British journal of pharmacology},
  year={2012},
  volume={167 5},
  pages={1076-88}
}
BACKGROUND AND PURPOSE N-arachidonoyl 5-HT (NA-5HT) has anti-nociceptive effects reported to be mediated by inhibitory actions at the transient receptor potential vanilloid receptor 1 (TRPV1) and fatty acid amide hydrolase (FAAH). Anandamide and N-arachidonoyl dopamine (NA-DA), endocannabinoids that activate TRPV1 or are metabolized by FAAH, also inhibit T-type calcium channels (I(Ca) ). T-type I(Ca) are expressed by many excitable cells, including neurons involved in pain detection and… CONTINUE READING
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