Inhibition of human primary melanoma cell proliferation by histamine is enhanced by interleukin-6.

@article{LzrMolnr2002InhibitionOH,
  title={Inhibition of human primary melanoma cell proliferation by histamine is enhanced by interleukin-6.},
  author={E L{\'a}z{\'a}r-Moln{\'a}r and Hargita Hegyesi and {\'E}va P{\'a}llinger and Peter Kovacs and Sara Toth and Carlos Fitzsimons and Graciela P. Cricco and Gr{\'e}goire Martin and Rosa M. Bergoc and Zs Darvas and Elena S. Rivera and Andr{\'a}s Falus},
  journal={European journal of clinical investigation},
  year={2002},
  volume={32 10},
  pages={743-9}
}
BACKGROUND Interleukin-6 (IL-6) is a bifunctional growth factor in malignant melanoma; its expression increases during the malignant progression of the disease. Histamine, detected in large amounts in normal and pathological proliferating tissues, is an important paracrine and autocrine regulator of normal and tumour cell proliferation as well. MATERIALS AND METHODS We investigated the presence and function of IL-6 and histamine in the WM35 primary human melanoma cell line with respect to… CONTINUE READING