Inhibition of human mesangial cell proliferation by targeting T-type calcium channels.


BACKGROUND Aberrant glomerular mesangial cell (MC) proliferation is a common finding in renal diseases. T-type calcium channels (T-CaCN) play an important role in the proliferation of a number of cell types, including vascular smooth muscle cells. The hypothesis that T-CaCN may play a role in the proliferation of human MC was investigated. METHODS The… (More)
DOI: 10.1159/000232590