Inhibition of human lung cancer cell line growth by an anti-p185HER2 antibody.

@article{Kern1993InhibitionOH,
  title={Inhibition of human lung cancer cell line growth by an anti-p185HER2 antibody.},
  author={Jeffrey A. Kern and Lisa Torney and David B. Weiner and Adi Gazdar and Harold Michael Shepard and BrianM. Fendly},
  journal={American journal of respiratory cell and molecular biology},
  year={1993},
  volume={9 4},
  pages={
          448-54
        }
}
p185HER2, the product of the c-erbB-2 or HER2 gene, is a membrane-bound tyrosine kinase that has structural similarity to the epidermal growth factor receptor. Functionally, interaction of HER2 with its ligand or p185HER2 antibodies affects the growth and differentiation of HER2-expressing breast cancer cell lines. As p185HER2 is also expressed in human lung cancers and human lung cancer cell lines, we hypothesized that these cell lines would also respond to p185HER2 antibodies. To test this… CONTINUE READING
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