Inhibition of human liver and duodenum sulfotransferases by drugs and dietary chemicals: a review of the literature.

@article{Pacifici2004InhibitionOH,
  title={Inhibition of human liver and duodenum sulfotransferases by drugs and dietary chemicals: a review of the literature.},
  author={Gian Maria Pacifici},
  journal={International journal of clinical pharmacology and therapeutics},
  year={2004},
  volume={42 9},
  pages={
          488-95
        }
}
  • G. Pacifici
  • Published 1 September 2004
  • Biology, Chemistry, Medicine
  • International journal of clinical pharmacology and therapeutics
Sulfotransferase catalyzes the transfer of sulfate, donated by 3'-phosphoadenosine-5'-phosphosulfate, to an acceptor substrate that may be a hydroxy group or an amine group. Man is exposed daily to drugs and dietary chemicals that can inhibit sulfotransferase activity. The aim of this study was to review the literature concerning the inhibition of sulfotransferases by drugs and dietary chemicals in the human liver and duodenum. The IC50 value of mefenamic acid for human liver phenol… 
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Opicapone Sulfation: Sulfotransferase Isoforms Characterization
TLDR
The kinetics for the conversion of opicapone into sulfated metabolite by intestinal, kidney and liver S9 fractions and by human recombinant SULTs were characterized, using sensitive and specific Liquid Chromatography tandem Mass Spectrometry (LC-MS/MS) equipment.
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