Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids.

Abstract

The inhibition of human leukocyte 5-lipoxygenase by 15-hydroperoxyeicosatetraenoic acid and its chemical or enzymatic rearrangement products was investigated. 15-Hydroperoxyeicosatetraenoic acid was the most potent inhibitor tested. The inhibition was found to be time dependent and is not due to chemical or enzymatic decomposition products nor metabolism of 15-hydroperoxyeicosatetraenoic acid to 5,15-dihydroperoxyeicosatetraenoic acid.

Cite this paper

@article{Cashman1988InhibitionOH, title={Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids.}, author={John Richard Cashman and Cherie Lambert and Elliott Sigal}, journal={Biochemical and biophysical research communications}, year={1988}, volume={155 1}, pages={38-44} }