Inhibition of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus in primary, mature islets of transgenic mice.

@article{Oetjen2003InhibitionOH,
  title={Inhibition of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus in primary, mature islets of transgenic mice.},
  author={Elke Oetjen and Diana Baun and Stephan Beimesche and Doris Krause and Irmgard Cierny and Roland Blume and C. C. Dickel and Simone Wehner and Willhart Knepel},
  journal={Molecular pharmacology},
  year={2003},
  volume={63 6},
  pages={1289-95}
}
Cyclosporin A and tacrolimus are clinically important immunosuppressive drugs. They share a diabetogenic action as one of their most serious adverse effects. The underlying mechanism is unknown. Previous studies have shown that tacrolimus can inhibit insulin gene transcription at high concentrations in tumor cell lines. To study insulin gene transcription in normal, mature pancreatic islet cells, we used a novel approach in the present study. Transgenic mice that carry a human insulin promoter… CONTINUE READING
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