Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor.

@article{Fletcher2009InhibitionOH,
  title={Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor.},
  author={Patricia E S Fletcher and Stuart. Harman and Hilde Azijn and Naomi Armanasco and Philippe Manlow and Deepak Perumal and M-P de B{\'e}thune and Joanne Nuttall and Jacob Romano and R Shattock},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 2},
  pages={487-95}
}
Heterosexual transmission of human immunodeficiency virus (HIV) remains the major route of infection worldwide; thus, there is an urgent need for additional prevention strategies, particularly strategies that could be controlled by women, such as topical microbicides. Potential microbicide candidates must be both safe and effective. Using cellular and tissue explant models, we have evaluated the activity of the nonnucleoside reverse transcriptase inhibitor (NNRTI) dapivirine as a vaginal… CONTINUE READING
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