Inhibition of human immunodeficiency virus type 1 integrase by the Fab fragment of a specific monoclonal antibody suggests that different multimerization states are required for different enzymatic functions.

Abstract

We have characterized a murine monoclonal antibody (MAb 35), which was raised against human immunodeficiency virus type 1 (HIV-1) integration protein (IN), and the corresponding Fab 35. Although MAb 35 does not inhibit HIV-1 IN, Fab 35 does. MAb 35 (and Fab 35) binds to an epitope in the C-terminal region of HIV-1 IN. Fab 35 inhibits 3'-end processing… (More)

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@article{Barsov1996InhibitionOH, title={Inhibition of human immunodeficiency virus type 1 integrase by the Fab fragment of a specific monoclonal antibody suggests that different multimerization states are required for different enzymatic functions.}, author={Eugene V. Barsov and Wade E Huber and Joseph Marcotrigiano and Philip Clark and A. D. Clark and Eric P Arnold and Steve Hughes}, journal={Journal of virology}, year={1996}, volume={70 7}, pages={4484-94} }