Inhibition of human immunodeficiency virus replication in cell culture by endogenously synthesized antisense RNA.

@article{Rhodes1990InhibitionOH,
  title={Inhibition of human immunodeficiency virus replication in cell culture by endogenously synthesized antisense RNA.},
  author={Audrey Rhodes and William James},
  journal={The Journal of general virology},
  year={1990},
  volume={71 ( Pt 9)},
  pages={1965-74}
}
Antisense RNA, which has a sequence complementary to mRNA, may provide the basis for antiviral therapies of high selectivity. We have explored the inhibitory effect of six antisense RNAs upon the replication of human immunodeficiency virus (HIV) in cell culture. We chose regions of the HIV genome to test whether sequences required for splicing or for… CONTINUE READING