Inhibition of human immunodeficiency virus envelope glycoprotein- mediated single cell lysis by low-molecular-weight antagonists of viral entry.

@article{Madani2007InhibitionOH,
  title={Inhibition of human immunodeficiency virus envelope glycoprotein- mediated single cell lysis by low-molecular-weight antagonists of viral entry.},
  author={Navid Madani and Amy M. Hubicki and Ana Luisa Perdigoto and Martin S. Springer and Joseph Sodroski},
  journal={Journal of virology},
  year={2007},
  volume={81 2},
  pages={532-8}
}
The coexpression of human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins and receptors leads to the lysis of single cells by a process that is dependent upon membrane fusion. This cell lysis was inhibited by low-molecular-weight compounds that interfere with receptor binding or with receptor-induced conformational transitions in the envelope glycoproteins. A peptide, T20, potently inhibited cell-cell fusion but had no effect on single cell lysis mediated by the HIV-1 envelope… CONTINUE READING

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