Inhibition of human immunodeficiency virus (HIV) infection in vitro by anticarbohydrate monoclonal antibodies: peripheral glycosylation of HIV envelope glycoprotein gp120 may be a target for virus neutralization.

@article{Hansen1990InhibitionOH,
  title={Inhibition of human immunodeficiency virus (HIV) infection in vitro by anticarbohydrate monoclonal antibodies: peripheral glycosylation of HIV envelope glycoprotein gp120 may be a target for virus neutralization.},
  author={J. E. S. Hansen and Henrik Clausen and Claus Meyer Nielsen and Lars Larsen Stubbe Teglbjaerg and Lise Lotte Hansen and Erik Dabelsteen and Lars R. Mathiesen and Senichiro Hakomori and Jens O. Nielsen},
  journal={Journal of virology},
  year={1990},
  volume={64 6},
  pages={2833-40}
}
Carbohydrate structures are often involved in the initial adhesion of pathogens to target cells. In the present study, a panel of anticarbohydrate monoclonal antibodies (MAbs) was tested for their ability to inhibit in vitro human immunodeficiency virus infectivity. MAbs against three different N- and O-linked carbohydrate epitopes (LeY, A1, and sialyl-Tn) were able to block infection by cell-free virus as well as inhibit syncytium formation. Inhibition of virus infectivity was independent of… CONTINUE READING