Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)beta-L-2',3'-dideoxy-3'-thiacytidine.

@article{King1998InhibitionOH,
  title={Inhibition of human hepatitis B virus replication by AT-61, a phenylpropenamide derivative, alone and in combination with (-)beta-L-2',3'-dideoxy-3'-thiacytidine.},
  author={Randy W. King and S K Ladner and T Justin Miller and K Zaifert and Robert B. Perni and S W Conway and Michael J. Otto},
  journal={Antimicrobial agents and chemotherapy},
  year={1998},
  volume={42 12},
  pages={3179-86}
}
AT-61, a member of a novel class of phenylpropenamide derivatives, was found to be a highly selective and potent inhibitor of human hepatitis B virus (HBV) replication in four different human hepatoblastoma cell lines which support the replication of HBV (i.e., HepAD38, HepAD79, 2.2.15, and transiently transfected HepG2 cells). This compound was equally effective at inhibiting both the formation of intracellular immature core particles and the release of extracellular virions, with 50… CONTINUE READING
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