Inhibition of human erythroid colony-forming units by interferons alpha and beta: differing mechanisms despite shared receptor.

@article{Means1996InhibitionOH,
  title={Inhibition of human erythroid colony-forming units by interferons alpha and beta: differing mechanisms despite shared receptor.},
  author={Robert T. Means and Sanford B. Krantz},
  journal={Experimental hematology},
  year={1996},
  volume={24 2},
  pages={204-8}
}
Previous investigations have demonstrated that interferons alpha, beta, and gamma (alpha-, beta-, and gamma-IFN) are potent inhibitors of erythropoiesis in vitro. By utilizing a cell population enriched for human erythroid colony-forming units (CFU-E), we have previously demonstrated that the inhibitory effects of beta- and gamma-IFNs are direct effects, not requiring the presence of accessory cells, and that the inhibitory effect of recombinant human (rh) gamma-IFN could be corrected by high… CONTINUE READING

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