Inhibition of human cytomegalovirus replication by 9-(1,3-dihydroxy-2-propoxymethyl)guanine alone and in combination with human interferons.

@article{Rasmussen1984InhibitionOH,
  title={Inhibition of human cytomegalovirus replication by 9-(1,3-dihydroxy-2-propoxymethyl)guanine alone and in combination with human interferons.},
  author={L. E. Little Rasmussen and Prof. Tinghuai Chen and J G Mullenax and Thomas C. Merigan},
  journal={Antimicrobial agents and chemotherapy},
  year={1984},
  volume={26 4},
  pages={441-5}
}
The inhibitory action of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on the replication of human cytomegalovirus was studied. Three laboratory strains (AD-169, Towne, and Davis) and three early passage (less than 10) clinical isolates were all inhibited in yield inhibition assays. In cultures infected with AD-169, virus yields could be inhibited if the drug was added as late as 3 days after the replication cycle had begun. The effects of the drug were fully reversible during the first 4 days of… CONTINUE READING