Inhibition of human cytomegalovirus maturation by brefeldin A.

  title={Inhibition of human cytomegalovirus maturation by brefeldin A.},
  author={Maren Eggers and Elke Bogner and Brian A Agricola and Horst F. Kern and Klaus Radsak},
  journal={The Journal of general virology},
  volume={73 ( Pt 10)},
Brefeldin A (BFA) was found to interfere with specific events of human cytomegalovirus (HCMV) maturation in human fibroblasts. Ultrastructural as well as biochemical studies suggested that short-term exposure of infected cultures to BFA during the late infectious cycle primarily prevented Golgi-dependent processes, e.g. envelopment of naked cytoplasmic nucleocapsids in the trans-Golgi network (TGN) and normal processing of glycoprotein B. In contrast, the nuclear phase of viral morphogenesis, e… CONTINUE READING


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